Liquorice, Liddle, Bartter or Gitelman—how to differentiate?

Cell cycle: To differentiate or not to differentiate?

We often think of cell-cycle progression and differentiation as two distinct and mutually exclusive processes during development. When cells continue to cycle they do not differentiate, and when cells terminally differentiate they no longer cycle. Thus, there is a temporal coupling between withdrawal from the cell cycle and differentiation. But what are the mechanisms that achieve such coupling...

Imitate or Differentiate ?

Although there is $2 trillion in portfolios using socially responsible investing (SRI) criteria, it remains unclear how to measure “social responsibility.” We explore competing theoretical perspectives that explain the level of convergent and predictive validity across SRI ratings produced by competing social raters. While some prior literature predicts low convergent validity due to desire for...

Lower limb monoparesis due to liquorice consumption

Since more than six decades ago, liquorice extracts have been used as treatment of gastroduodenal ulcers or Addison’s disease, as adjuvant sweetener in medical mixtures and even as a sweet for children. However, the first case reports on severe side effects of liquorice consumption were observed in the Netherlands back in the 1940s [1]. Hypokalaemic respiratory muscle paralysis due to liquorice...

Bartter syndrome

Hypertension induced by liquorice tea.

A 45-year-old woman presented to her general practitioner with a 4-month history of hot flushes, sweating and headaches. On examination, she was found to be hypertensive, and blood tests revealed mild hypokalaemia. While awaiting the results of further investigation into the cause of her elevated blood pressure, the patient conducted her own research and identified liquorice tea as the potentia...